What Is A Tablet Coating Machine: Principle, Types & Benifits

- Monday, April 10,

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Whether you intend to invest in tablet production equipment or simply want to learn about the tablet manufacturing process, tablet coating machines are a crucial part that should never be overlooked.

So, what is a tablet coating machine? If you want to get a rough idea of tablet coating or make an informed decision before purchase, this 101 guide will walk you through all the basics you need to know about the equipment.

First, what is a tablet coating machine?

Tablet coating machines are mechanical devices designed to perform a simple process of applying a thin layer of coating material to the surface of the tablets. They deliver a bunch of benefits by placing a coating solution around the solid oral dosage form.

Why should you use a tablet coating machine?

A tablet is typically formulated with one or more active pharmaceutical ingredients (APIs). The properties of many APIs are highly sensitive to the environment, so they need to be protected by a film of coating against external influences. Here's why you should use tablet coating equipment.

1. To mask the unpleasant taste and odor of tablets;
2. To make swallowing large dosage forms easier for children and the elderly;
3. To provide tablets with an attractive appearance;
4. To improve patient compliance;
5. To enhance the dosage form's mechanical strength;
6. To protect medicines from external environmental factors such as air, moisture, and light while also providing physical and chemical protection for the medication;
7. To combine incompatible APIs in a single dosage form;
8. To prevent the medicine from dissolving in the acidic environment of the stomach;
9. To modify and regulate medication release from tablets by creating products with a delayed-release and sustained-release formulation.

How does a tablet coating machine work?

Though tablet coating machines are classified into multiple types, their principles are more or less similar to one another. If you're curious about how different tablet coater works, we'll talk about that later. So, let's carry on.

Typically, the tablet coating equipment performs a process that includes the following 7 steps:

1. Preparation: Batch identification and selection of coating solution recipe;
2. Loading: A batch of tablets is loaded into the coating pan by the operator;
3. Warming: Preheat the tablets until they reach the set temperature;
4. Spraying: As the tablets rotate continuously in the coating pan, the coating solution is automatically and evenly distributed onto the tablets by an air-atomized spray system;
5. Drying: At the same time, heated air is directed into the coating pan under negative pressure. The heated air passes through the tablets so that the coating solution sprayed on the tablet cores will dry fast, producing a solid and smooth film on the surface of the tablets;
6. Cooling: The spray guns stop. The pan keeps rotating, enabling the coated tablets to tumble and cool down;
7. Discharging: After the batched tablets are completely coated and cooled down, unload them for the downstream process.

Read More:

The 9 Most Important Parts of a Tablet Coating Machine

Common Tablet Coating Defects: Troubleshooting Guide

What are the types of tablet coating machines?

As mentioned above, there are many types of tablet coating machines in the market. They are:

• Standard coating pan

A standard coating pan comes in a metal pan with a circular opening. The coating pan is mounted at an angle of 30-45 degrees on a stand. The diameter of the coating pan can range from 15 to 200 cm, meeting different production needs.

This conventional coating pan rotates about its horizontal axis, enabling the tablets to tumble inside the pan. Also, it uses an air-atomized spray system to apply the coating solution equally to each and every tablet. At the same time, the heated air is drawn into and leaves the pan through the circular opening to complete the drying process.

Since this tablet coating machine is a conventional type, it has undergone many modifications. There are three types of systems working to enhance drying efficiency.

1. Pellegrini pan system
2. Immersion sword system
3. Immersion tube system

• Perforated pan or drum

A perforated pan or drum is the most efficient and widely used tablet coating equipment in the industry.

This machine has a drum that is either completely or partly perforated. The drum spins on a horizontal axis in an enclosed housing to coat tablets. Spraying nozzles are used in the perforated pan to uniformly distribute the coating solution to the surface of the rotating tablet bed.

As with the standard coating pan, the perforated pan system also come in a range of variations to improve coating and drying efficiency.

1. Accela-cota
2. Hi-coater
3. Driacoater
4. Glatt coater

• Fluidized bed or air suspension system

Fluidized bed coaters, also known as air suspension systems, are highly efficient machines that employ fluid bed technology for tablet coating.

The equipment uses spray guns to apply the coating material to the tablets. In this system, tablets are suspended in an upward airflow, exposing the maximum area to allow the coating solution and drying air to contact more tablets more quickly.

The top spray, bottom spray, and tangential spray methods are the primary patterns applied to this process.

Benefits of using tablet coating equipment

What is a tablet coating machine? How does it work? I bet the third question hovering in your mind must be: what can you benefit from the equipment?

• Advantages of standard coating pan

1. It can be used for both sugar and film coating processes;
2. The air-atomized spray system allows the coating solution to be distributed more quickly and evenly;
3. The spray system helps shorten the drying time of sugar coating and allows for continuous film coating;
4. The equipment can greatly improve the drying efficiency by employing the Pellegrini pan system, immersion sword system, and immersion tube system.

• Advantages of perforated pan

1. It's applicable for both sugar and film coating processes;
2. The most widely used and efficient coating pan system;
3. The equipment is well designed to enhance drying efficiency;
4. Multiple airflow configurations are available in Glatt coaters.

• Advantages of fluidized bed or air suspension system

1. This system is capable of suspending and coating tablets at the same time to achieve higher production efficiency;
2. A high-performance alternative to pan coating;
3. It's widely used for coating multiple unit dosage forms;
4. The equipment features two spray systems: a high-pressure airless system and a low-pressure air-atomized system, allowing a precise and ultra-fine spray to achieve a perfectly uniform film coating.

Basic requirements of a tablet coating machine

No matter what type of euiqpment you prefer, there are some basic requirements you need to know when selecting automatic tablet coating mamchine manufacturers.

1. The equipment should be well designed to easily and evenly distribute the coating solution onto the tablets;
2. The equipment should ensure a uniform, smooth, and dust-free surface of the coated tablet;
3. The tablet cores have to be more robust than uncoated ones since they have to survive additional processes;
4. Use biologically inert material or solvent to coat tablets.
5. Each piece of equipment should be GMP or cGMP compliant.

Final words

If you&#;ve ever had these questions in mind: What is a tablet coating machine? How does it work? What are the benefits of using such a machine? You must have found the answers in this 101 guide.

Tablet coating machines must be efficient enough to catch up with your tablet production. At iPharMachine, we offer a range of tablet coating equipment models of the highest quality for every need. Contact us today to learn more!

A Tablet coating machine is used to provide a coating over uncoated tablets, which protects them from environmental moisture, and chemical degradation and masks the bitter taste of the drug, etc. Also, the Coating machine shall have provision for film coating (Aqueous / Non-Aqueous) and sugar coating with interchangeable type coating pans of different capacities.

Working principles of tablet coating machines:

 Tablet coating equipment simply worked by applying solution spray on the compressed tablet in a bed that will move horizontally and vertically. A uniform flow of heated air will dry the coat of the tablet and facilitate the evaporation of solvents.

Brief:

Compressed tablet spinning involves putting the tablets in a drum and rotating it in an orbital way. As the drum spins, a nozzle sprays a coating solution Aqueous / Non-Aqueous) onto the tablets. Automation ensures there are accuracy and an even and uniform spray on the tablets. This has baffles installed in a drum at a particular angle and turn tables facilitating sideways even spraying of the tablets, while the spaying and rotation continue, the machine pumps hot air into the drum which results in the rapid coating of the solution. After all the tablets have a uniform coating, the spinning and spraying stopped, and the tablets then proceed to the drying section.

Types of tablet coating machines:

There are many types of coating machines in the market. Mostly we categorize coating machines on the basis of their pan & working principles. Below are the types of coating machines

1. Standard coating pan

   • Pellegrini pan

   • Immersion sword system

   • Immersion tube system

2. Perforated coating pan

• • Accela-Cota

  • Hi-coater systems

  • Driacoater

  • Glatt coater

3. Fluidized bed or air suspension coater

• • High-pressure airless systems

  • Low-pressure air atomized systems

Key Process Parameters:

The coating system must be able to monitor and control the below-listed key process parameters

Parameter

Range

Accuracy

Spray rate/gun

20-90 g/min

± 5 g/min

Pan speed (rpm)

0.5-20rpm

±1rpm

Airflow (Inlet air fan speed rpm)

m3/hour

m3/hour

Inlet air temperature

25-90ºC

±3ºC

Outlet air temperature

25-70ºC

±3ºC

Product temperature

25-70ºC

±3ºC

Inlet air humidity (desiccant system)

3-10 g/Kg

±1 g/Kg

The angle of spray guns

0, 20, 40, 60, 80 -90deg

NA

Atomizing air pressure (MPA)

1- 6 Mpa

0.1  Mpa

Distance of spray guns to tablets bed

15-30 mm

NA

Key Quality Attributes:

The product to be processed in the required coating system must comply with the specs of the below key quality attributes.

Parameter

Contact us to discuss your requirements of coating line machine. Our experienced sales team can help you identify the options that best suit your needs.

Range

weight gain percentage for film coating

1-5%

Weight gain percentage for Sugar coater

50-100%

Quantity of film coat applied on tablet total surface area

3.0-5.0mg/cm2  It depends upon the % weight build-up and tablet surface.

Major Components of Coating Machine:

 Drive Component:

• Main Power Driving Motor and brim rollers.
• Main Power Driving Motor Variable Frequency Drives (inverter).
• Speed change should be smooth without any jerk and noise.
• The minimum pan speed range should be 1 RPM
• Maximum pan speed range should be 20.0 RPM
• The machine should have intermittent drive mode for pre-heating of core tablets before the spraying phase and drying& cooling of coated tablets after the termination of the spraying phase.
• Intermittent drive mode should have settable parameters.

Coating Pan:

• Coating pans of specific diameter along with coating pan trays (Trolleys). It may be interchangeable as per your requirement.
• The coating pan should have an output capacity at tablet density 0.7g/ml.
• Coating Pans should be perforated with a size of perforation 2.5 mm round.
• The tablet coater must have a percentage drum perforation of &#;25%.
• Coating Pans and their baffles should be made of SS 316L material and the surface of the pan should be polished for easy cleaning and maintenance.
• Pan should rotate in a clockwise direction during the preheating, coating process, and cleaning process and anti-clockwise direction during tablet discharge.
• The coater pan should be fitted with low-shear mixing baffles to tumble the tablet cores allowing uniform coating across the full load range of the coater.
• The tablet unloading (Discharging) should be automatic without damaging the coated tablets.
• The tablet coater should be fitted with a transparent viewing port, allowing the operator to check the internal of the pan.

• The tablet coater must maintain negative differential pressure to the coating suite with the sample port, service door, or main front door open.
• Hot inlet air should be supplied to the coating pan through the supply duct and should move inside the coating pan. The air inside of the coating pan should move through the tablet bed and then air should exhaust to the dust collector through an exhaust duct.

Spray gun:

• Spray guns provide efficient and uniform coating, along with smoother operation
• The coating machine should be supplied with anti-bearding Schlick guns with high volume at low-pressure type.
• The spray nozzle size should be 1.0mm.
• Depending on the depth of the coating pan fixed on the coating machine, the number of guns should be increased or decreased.
• The atomizing air pressure for each gun should be monitored with the help of a human-readable and or digital measuring device and can be adjusted from the regulator and or HMI.
• Provision shall be provided for easy adjustment of spray gun angle with respect to the coating bed as well as adjustment of the distance between the coating bed and spray.
• There should be minimum exposure of solution tubes and pneumatic tubes of spray guns within the coating pan.
• If the machine (coating pan) stops suddenly or due to any alarm, the spray gun will also stop functioning to avoid any drop of solution to the tablet&#;s bed.

Damper:

• The machine will be supplied with Auto Damper for the inlet and an outlet with a bypass flap for hot air.
• Steam-based heating with PID-controlled face/bypass system to ensure accurate air temperature control
• Temperature measurement to measure and control the for-inlet air temperature.
• The actuator positions should be programmable based on the coating cycle (film coating or sugar coating).

Pump & it&#;s manifold:

• The mostly multi-head peristaltic pump distributes spray liquid evenly to each nozzle through a spray manifold inbuilt into the spray arm. Supplied mounted on the machine frame.
• Pumping system Integrated with control system
• Pressure transmitter to detect gun choking
• A rotary pump will be used for Sugar coating. The pump transports the spray liquid to the in-feed rake because in case of the sugar-coating solution is viscous.
• Frequency converter for the speed adjustment of the spray pump
• The Film coating pump with Adjustable RPM speed and The RPM of the pump can both be controlled from the HMI or the pump itself.

The calculation for the Capacity tablet coating machine:

The capacity of a tablet coating machine in the pharmaceutical industry can be calculated using the following formula:

Capacity = (Tablet weight x Batch size x Coating time) / Coating efficiency

Here are the steps to calculate the capacity:

1. Determine the weight of each tablet. This can be obtained by weighing a sample of tablets and dividing the total weight by the number of tablets.
2. Determine the batch size, which is the total number of tablets to be coated in a single batch.
3. Determine the coating time, which is the total time required for coating a batch of tablets. This includes the time for loading and unloading the tablets, as well as the actual coating time.
4. Determine the coating efficiency, which is the percentage of coating material that actually adheres to the tablets. This can be determined through trial runs and adjusting the machine settings accordingly.
5. Plug in the values into the formula:
   1. • Capacity = (Tablet weight x Batch size x Coating time) / Coating efficiency

By following these steps and using the formula, you can calculate the capacity of a tablet coating machine in the pharmaceutical industry.

Critical Parameters of a tablet coating machine

The critical parameters of a tablet coating machine in the pharmaceutical industry are:

1. Inlet Air Temperature: The inlet air temperature is a critical parameter as it affects the drying time and the quality of the coating. The temperature needs to be controlled to ensure the tablets are not overheated, which can cause degradation or melting of the coating.
2. Spray Rate: The spray rate is the amount of coating solution that is sprayed onto the tablets per unit of time. It is critical to ensure that the spray rate is consistent throughout the coating process to achieve a uniform coating thickness.
3. Atomization Pressure: The atomization pressure is the pressure at which the coating solution is sprayed onto the tablets. It is essential to maintain the correct atomization pressure to ensure proper droplet size and distribution, which affects the quality and uniformity of the coating.
4. Pan Speed: The pan speed is the speed at which the tablet bed rotates in the coating pan. The pan speed needs to be carefully controlled to ensure that the tablets are evenly coated and that there is no over-coating or under-coating.
5. Coating Solution Viscosity: The coating solution viscosity is a critical parameter as it affects the spray rate, atomization, and drying time. A high viscosity can result in uneven coating, while a low viscosity can cause the coating to be too thin and easily damaged.
6. Exhaust Rate: The exhaust rate is the rate at which the air is removed from the coating chamber. It is critical to maintain the correct exhaust rate to ensure that the tablets are properly dried and to prevent the buildup of solvents or coating material in the coating chamber.
7. Coating Solution pH: The pH of the coating solution is important as it affects the stability and solubility of the coating material. A pH outside the recommended range can result in a poor-quality coating or even damage to the tablets.

By closely monitoring and controlling these critical parameters, a pharmaceutical manufacturer can ensure that their tablet coating machine is producing tablets with a high-quality, uniform coating that meets the required specifications.

Air Processing unit (APU) with Heat exchanger:

• The APU should supply filtered and hot air to the coating pan through the supply duct.
• Double-walled inlet air unit with dehumidification and heating system. Automatically controlled inlet air temperature, airflow speed, and dehumidification chamber temperature through PID. Humidity measurement at the inlet of the machine.
• Internal wall MOC &#; SS304
• External wall MOC &#; Galvanized Iron, powder coated
• Filter frames &#; Aluminum
• Provided with limit switches on all doors, interlocked with control system
• Provided with HEPA validation ports

Filter Set EU4/EU7/EU13 

Pre-Filter 

• Pre-filter Grade EU4
• 85-90% down to 3 microns
• Equipped with a Magnehelic gauge for local differential pressure indication

Fine Filter 

• Fine filter Grade EU7
• 85% down to 0.3 microns
• Equipped with a Magnehelic gauge for local differential pressure indication

HEPA Filter 

• HEPA filter Grade EU13
• 997% down to 0.3 microns
• Equipped with a Magnehelic gauge for local differential pressure indication

Equipped with a differential pressure transmitter for indication on HMI.

APU consists of a heating coil to heat the filtered air. The steam valves should automatically be controlled with the help of the software PID controller working in concordance with the PLC commands and the user input temperature set on the HMI of the machine.

The present temperature of Inlet air shall be displayed on the variation in actual and the set temperature should not be more than + 3.0 °C. Temperatures (with PT100): +/- 1 % of the measuring range

The machine has auto spray cutoff provision interlock with inlet temperature (when inlet temperature breaches the upper and lower temperature set point for inlet air).

The maximum set value for inlet temperature will be 90°C (higher than this is acceptable).

Dust collector:

• Dust collector for exhaust and discharge the air from the coating pan through the exhaust duct.
• Active exhaust air deduster unit with H10 filter. Equipped with a removable dust collecting container with quick release for the dust of filter stage. Automatically controlled air purging integrated with a differential pressure switch. Additional passive H13 filter.
• The dust collector has cartridge filters through which the exhaust air should pass.
• These filters should trap the waste powders and suspend them onto the tray at the bottom of the dust collector.
• Dust collector has the function of exhausting and discharging the air from the coating machine. By going through the dust collector, air with the dirt is cleaned by the cartridge filter. The temperature of the exhausted air should be checked by the sensor and displayed in HMI
• The dust collector should consist fan and the speed of the fan is controlled by the inverter

Wet Scrubber:  

A wet scrubber is used by transferring solid particles from a gas stream to a liquid, wet scrubber procedures remove them from the stream. The energy required to touch the gas stream with the scrubber liquid determines how effectively a wet scrubber collects particles.

CIP System:

• The machine shall be supplied with a CIP system (Clean In Place System) that
• The CIP system should supply high-pressure water the to CIP points located in the coating pan.
• The clean-In-Place system consists of strategically placed washing nozzles to ensure hassle-free cleaning validation in a low-downtime environment.
• Machine constructed to minimize crevices and difficult-to-reach areas
• WIP Skid consists of a Media supply with connections for o Warm water
• Cold water
• Purified water
• Compressed air
• These connections are equipped with check valves to prevent back-flow
• Flow switch
• Booster Pump
• Distribution valves
• Control System
• CIP system ensures complete cleaning of a coating pan, spray guns, supply, and exhaust ducts, and ensures complete drains of water used for cleaning from the machine.
• All wash water contact parts must be compatible with pharmaceutical-grade detergents with a range of 1.5 to 13.7 pH.

Control System:

The machine has a fully automated control panel

• The machine has both supply temperature controller mode and exhaust temperature controller mode.
• The machine has displayed DPIP (Differential pressure inside the pan) and DPIE Differential pressure inside the exhaust.
• The machine has displayed supply velocity (In CFM) and Humidity (in obsolete term g/kg).
• A pressure gauge shall be provided for measuring Differential pressure across the HEPA filter.
• The auto-coating should be recipe controlled.
• The CIP cycle should be recipe controlled.
• The operator should not be able to modify or delete the parameters of the stored recipe.

The recipe should have set points for the following (Not limited to):

• &#;Exhaust Temperature set
• &#;Exhaust Fan Speed
• &#; Supply Temperature
• &#; Supply Fan Speed
• &#; Spray Atomizing Air pressure
• &#; Coater Differential Pressure
• &#; Coater Pan Speed
• &#; Solution Pump Speed
• &#;Machine should have audiovisual alarms.
• &#;Machine should have alarms for the following:
• &#; Main air shortage
• &#; Trip coater motor
• &#; Trip exhaust fan motor
• &#; Trip supply fan motor
• &#; Completed Film coating/sugar coating
• &#; Exhaust temp over limit/exhaust temp low limit
• &#; Glass open
• &#; Buzzer Off/On Select
• &#; Product temp over / low limit
• &#; Supply temp over / low limit
• &#; Solution tank temp over / low limit
• &#; D.P.I.P High/low
• &#; D.P.I.E High/low
• &#; Communication failure 21CFR Part 11 requirements (There are bare minimum requirements)

Safety Features:

• The machine shall have to earth.
• Safety interlock to prevent operator access to rotating parts.
• Emergency switch and control panel for immediate shut down of the machine.
• In a power failure or emergency stop condition, all equipment or component parts not required for equipment protection MUST have all stored energy dissipated or prevented for activation by a fail-safe system
• The coating machine shall be flameproof with the following specification,
• Flameproof &#; Suitable for groups II (B) and III (B)
• Rating &#; Exd (Atex approval)
• Ingress protection (IP) &#; 65 (minimum)
• Temperature rating &#; it should be minimum T4
• MOC of product contact parts &#; SS316L / higher grade with surface finish Ra of <0.5 μm
• Contact parts provided in food grade Silicon/EPDM

Documentation required:

• MOC / COA certificate of contact and noncontact PARTS.
• MOC food grade and nontoxic certificates of contact and noncontact gaskets
• Electrical diagram
• Sets of maintenance and operational manual
• Functional specification and design specification (FS/DS)
• Calibration certificates of gauges and instruments with traceability certificate
• Operational manual of automated or PLC system / MMI
• Operational & maintenance manuals for the coater.
• Maintenance Manual
• PLC input/output list
• PLC and control panel wiring diagram
• List of alarm and their rectification procedure
• List of functional authorization
• FAT / SAT document
• GA (General alignment) drawing
• Schematic diagram of the machine showing overall dimension (as built drawing)
• System architecture diagram configuration and calibration certificate
• Alarm list (diagnostic and system created)
• FAT and installation qualification protocol
• Flameproof certificate of motor and accessories
• Certificate of HEPA filter and test certificate and certificate of another filter
• P&ID (Piping and instrumentation diagram)
• PLC backup
• Complete set of DQ, and IQ   Documents.
• All documents are as per URS

Manufacturer of Coating Machine

There are lots of manufacturers worldwide who manufacture Tablet Coating machines,  some of the best manufacturers are below:

1. Glatt.
2. Solace Engineers.
3. Sejong.
4. Gea Process equipment.
5. ACG
6. Prism

Frequently Asked Questions (FAQ) for Coating Machine:

What is a coating machine?

Answer: coating machine is used to do the coating of the solution on the compressed tablet.

What is the principle of coating?

Answer: The principle of the coating Machine is the spraying of the solution on the tablet with moving bed tablets, and the solvent is spayed to it using a stream of hot air to this moving pan.

How many types of coating machines are there?

Answer: There are two types of coating tablets in pharmaceuticals which are sugar coating & polymer film coating Machine.

What is the purpose of a tablet coating machine in pharmaceuticals?

Answer: A tablet coating machine is used to apply a thin layer of coating material onto tablets, serving purposes such as improving appearance, taste, stability, and controlled-release properties.

How does a tablet coating machine work?

Answer: A tablet coating machine typically consists of a rotating drum or pan where tablets are placed. The coating material is sprayed onto the tablets while they tumble in the drum. The machine may have features to control temperature, airflow, and spray rate for uniform coating application.

What are the types of coating materials used in tablet coating machines?

Answer: Tablet coating materials can include polymers, sugar-based substances, and other coating agents depending on the desired properties and requirements of the tablets.

What is the importance of uniform coating application?

Answer: Uniform coating application ensures consistent quality and effectiveness of the tablets, as it ensures that each tablet receives the appropriate amount of coating material.

How is the drying process achieved in tablet coating machines?

Answer:After the coating material is applied, the tablets undergo a drying process using heated air. The machine&#;s design and airflow patterns facilitate the efficient removal of moisture from the coating, ensuring a dry and stable final product.

Can tablet coating machines apply multiple layers of coating?

Answer: Yes, tablet coating machines can apply multiple layers of coating if necessary. This allows for the creation of complex formulations or specific release profiles.

How is the coating solution supplied to the tablet coating machine?

Answer: The coating solution is supplied to the tablet coating machine through a spraying system that includes a spray gun or nozzles. The solution is typically stored in a reservoir connected to the spraying system.

What factors are controlled during the tablet coating process?

Answer: During the tablet coating process, factors such as temperature, airflow, spray rate, and the angle of the drum or pan can be controlled to ensure optimal coating results and efficiency.

What are the challenges associated with tablet coating?

Answer: Challenges in tablet coating can include achieving uniform coating thickness, preventing tablet damage or sticking, controlling the drying process effectively, and maintaining batch-to-batch consistency.

How important is the selection of a tablet coating machine for pharmaceutical manufacturers?

Answer: The selection of a tablet coating machine is crucial for pharmaceutical manufacturers as it directly impacts the quality, efficiency, and productivity of tablet production. Factors such as capacity, coating flexibility, ease of cleaning, and compliance with regulatory standards should be considered when choosing a tablet coating machine.

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