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Do you know if you are using R grade HPC? If so it wont clump together and you can add it to the vortex of well agitated room temperature water and let it stir until it is fully hydrated. It will also thicken with other solvents like ethanol and pg. I have only used it in aqueous solutions, though.
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If you are using R grade HEC it will delay hydration so that it doesnt clump together. It needs to be stirred until fully hydrated which can take up to 25 minutes. I add it to room temperature water, but It will hydrate faster with a higher ph and temperature, but too high can cause lumping. Once its fully hydrated it can be heated and ph can be adjusted.
I know you didnt mention HPMC, but I will add the instructions I used for it in case in the future you work with it. With HPMC you want to heat 1/3 of the water from the total water in your formula to 75C and then add the HPMC to vortex of agitated water, it wont dissolve in hot water but it will disperse evenly. When the HPMC is dispersed add the rest of the room temperature water and stir for 30 minutes. When the temperature is below 25C, continue with the rest of the formula.
Instructions can vary depending on the manufacturer of the ingredient, though.
I have been using Ashland Benecel E10M HPMC, Natrosol 250 HHR CS HEC, and Klucel H CS HPC
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